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celecoxib decreases effects of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Helps prevent conversion of codeine to its Lively metabolite morphine.promethazine raises effects of daxibotulinumtoxinA by pharmacodynamic synergism. Use Warning/Watch. Drugs with anticholinergic effects may well potentiate botulinum to